While re-watching David LO Smith’s workshop video that he did for last years virtual show I was reminded that quite often the job itself doesn’t present the biggest problem for machine tools it’s holding the item securely in the right orientation that proves most challenging.
Needing to drill out some cast brass brake hangers and shoes I was struggling on how to hold them because the castings were ever so slightly miscast meaning that each part had to be slightly tilted to get the hole to go through cleanly without coming out of the side of the casting.
I thought I would share with you the method that I came up with.

I gripped the pliers in the small machine vice and bought the drill bit down in front of the part to check alignment, adjusting until the hole would pass through the casting correctly before aligning the drill bit over the point to be drilled. 
I have had these pliers for years and I removed the spring for a job and never put it back this means that the jaws stay where you put them so ideal for using both hands to do the set up. 
They have quite straight but quite narrow jaws (3mm for most of their length tapering to 2.6mm at the ends) and I wish I could buy another pair as using them for soldering many times has started to corrode the ends of the jaws.
Then to start drilling grip the handles of the pliers to keep the part in place and operate the drill with the other hand. I had to keep minutely adjusting the angle as I drilled each end of each casting but all six were drilled both ends without mishap.